Mg facilitates leader peptide translation to induce riboswitch-mediated transcription termination
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چکیده
Should you be able to address these criticisms in full, we could consider a revised manuscript. I should remind you that it is EMBO Journal policy to allow a single round of revision only and that, therefore, acceptance or rejection of the manuscript will depend on the completeness of your responses included in the next, final version of the manuscript. This is particularly pertinent since the highly related Cell paper was published before submission of this manuscript, and the Cell paper would certainly have to be cited and discussed, in particular in light of the apparent discrepancies regarding the Proline data, as raised by all the referees.
منابع مشابه
Mg2+ facilitates leader peptide translation to induce riboswitch-mediated transcription termination.
We have characterized a 17-residue peptide, MgtL, which is translated specifically in high Mg(2+) from an open reading frame (ORF) embedded in the Mg(2+) riboswitch domain, previously identified in the 5' leader region of Mg(2+) transporter gene mgtA in Salmonella. We demonstrate that mgtL translation is required to prematurely terminate mgtA transcription. Abrogation of mgtL translation by mut...
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Riboswitches are regulatory elements that control gene expression by altering RNA structure upon the binding of specific metabolites. Although Bacillus subtilis riboswitches have been shown to control premature transcription termination, less is known about regulatory mechanisms employed by Escherichia coli riboswitches, which are predicted to regulate mostly at the level of translation initiat...
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تاریخ انتشار 2011